Berberine Activates the “Master Metabolic Switch” AMPK and Is A Huge Bio-Hack - Ascent Nutrition

Ascent Nutrition

Brain, body, and blood sugar are all critical to maintaining optimal performance and berberine has the ability to affect all of these in a powerful way!

Berberine can be a powerful ally in achieving profound differences in response to your dietary intake and efficacy of exercise. Berberine is so unique thanks to its many benefits, so we are going to take a deep dive on how it all works.

Berberine is a plant alkaloid found in a wide variety of herbs, such as goldenseal, Oregon grape, and tree turmeric. Found in the stem, bark, roots and rhizomes of the plants, it has been used for thousands of years ago in Traditional Chinese Medicine and Ayurvedic medicine.

Traditional usage was for diarrhea and gastrointestinal issues while modern studies are beginning to prove it’s multi-pronged effects, including cognitive function, promoting longevity, and a healthy response to oxidative stress.[1]

Plant Pharmacology in Action!

Could a plant alkaloid help you live longer? Berberine activates what is known as the adenosine monophosphate-activated protein kinase (AMPK). AMPK is an enzyme that acts as a master metabolic switch in each of your cells.

When AMPK is activated you get a myriad of benefits including more energy, healthy blood glucose, insulin sensitivity, healthy triglycerides, and metabolic flexibility in mitochondria.[2] AMPK activation is commonly associated with fasting, exercise, and supplementing, all helping to burn more fat molecules and guard mitochondrial efficiency.[3]

Berberine works to increase its phosphorylation in the brain cells, triggering elevated AMP/ATP levels to reduce oxygen consumption thanks to a process known as glycolysis.[4]

This stimulation of glycolysis means more efficient mitochondria, boosted cognitive function and memory.[5]

Switching on Your Genes

Over our lifetime, levels of AMPK in the body start to decrease as a result of not eating the right foods in right amounts in combination with our environment. This can impair genes that promote longevity and instead add to inflammation within the body.

Berberine not only activates these AMPK pathways to promote longevity and overall wellness, but it also affects various other molecules inside cells, which may even affect which genes are turned on or off.[6]

Research finds that Berberine benefits to cognition is attributed to it’s ability to activate sigma-1 receptors in the brain. Activation at these receptors raises BDNF levels and helps optimize NMDA activity.

Brain-Derived Neurotrophic Factor (BDNF) is correlated with learning, memory, synaptic responses, and overall mood & wellbeing.[7] This may attribute to Berberine’s testimony of promoting a sense of well-being among other therapeutic effects.

You may never know what the full potential of your body is until you turn on your genes! Berberine is one of the very few promising health-promoting substances that may be one of the top ones to include in your arsenal.

Check out our Berberine Complex which includes Bitter melon and Banaba Leaf available now!

[1] https://pubmed.ncbi.nlm.nih.gov/22842630/

[2] https://pubmed.ncbi.nlm.nih.gov/8557660/

[3] https://pubmed.ncbi.nlm.nih.gov/28974774/

[4] https://pubmed.ncbi.nlm.nih.gov/26855936/

[5] https://pubmed.ncbi.nlm.nih.gov/30737462/

[6] https://pubmed.ncbi.nlm.nih.gov/24174332/

[7] https://pubmed.ncbi.nlm.nih.gov/28928987/

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